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The mean elimination half-life (±SD) of Bupropion after chronic dosing is 21 (±9) hours, and steady-state plasma concentrations of Bupropion are reached within 8 days. Three metabolites have been shown to be active: hydroxyBupropion, which is formed via hydroxylation of the tert-butyl group of Bupropion, and the amino-alcohol isomers threohydroBupropion and erythrohydroBupropion, which are formed via reduction of the carbonyl group. The potency and toxicity of the metabolites relative to Bupropion have not been fully characterized. ) or elimination may be expected to influence the degree and extent of accumulation of the active metabolites of Bupropion. 5%, a finding consistent with the extensive metabolism of Bupropion. In vitro findings suggest that cytochrome P450IIB6 (CYP2B6) is the principal isoenzyme involved in the formation of hydroxyBupropion, while cytochrome P450 isoenzymes are not involved in the formation of threohydroBupropion.
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